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Creators/Authors contains: "Flynn, Jake R"

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  1. null (Ed.)
    Data-rich environments rely on operators to collaborate, especially in light of workload changes. This work explores the relationship between the operators’ shared visual attention patterns on a target area of interest (AOI), i.e. the AOI causing a workload change, and how it affects collaborative performance. Eye tracking data was collected from ten pairs of participants who completed two scenarios, the first being low workload and the second being high workload, in an unmanned aerial vehicle (UAV) command and control testbed. Then, best and worst performing pairs were compared in terms of two shared visual attention metrics: (1) percent gaze overlap and (2) the phi coefficient for the target AOI. The results showed that coordinated visits to and from the target AOI were associated with better performance during high workload. These results suggest including quantitative measures of visual attention can be indicators of the adaptation process in real- time. 
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  2. null (Ed.)
    Platelets are currently stored at room temperature before transfusion to maximize circulation time. This approach has numerous downsides, including limited storage duration, bacterial growth risk, and increased costs. Cold storage could alleviate these problems. However, the functional consequences of cold exposure for platelets are poorly understood. In the present study, we compared the function of cold-stored platelets (CSP) and room temperature-stored platelets (RSP) in vitro, in vivo, and post-transfusion. CSP formed larger aggregates under in vitro shear while generating similar contractile forces compared to RSP. We found significantly reduced GPVI levels after cold exposure of 5-7 days. After transfusion in humans, CSP were mostly equivalent to RSP yet aggregated significantly less to the GPVI agonist collagen. In a mouse model of platelet transfusion, we found a significantly lower response to the GPVI-dependent agonist convulxin and significantly lower GPVI levels on the surface of transfused platelets after cold storage. In summary, our data support an immediate but short-lived benefit of CSP and highlight the need for thorough investigations of this product. (NCT03787927) 
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